Endocrine Abstracts

Thyroid hormones (T4 and T3) have a major role in brain development, and their deficits during critical stages during the fetal and neonatal periods may cause profound intellectual and neuromotor deficits. A particular example is the X-linked Allan-Herndon-Dudley syndrome, caused by mutations of the cellular transporter for thyroid hormone MCT8 (SLC16A2). In this presentation I will first review the pathophysiology of thyroid hormone transport and metabol...